Week 12 NFL: Top 3 Against the Spread Picks with Full Odds Board

Detroit is at home as a big favorite against a Giants team that is banged up on both sides of the ball and missing its starting quarterback. The Giants have struggled to move the ball without Jaxson Dart, and they come into this game with multiple defensive starters either out or limited. That is a bad setup against a Lions offense that can score in bunches when they are indoors.

The spread is big, but so is the mismatch. Detroit has a clear advantage on the offensive line, in the passing game and in red zone efficiency. With a double digit spread, you want a team that will keep scoring rather than sitting on a small lead. The Lions fit that profile at home in a must handle business spot against a weak opponent.

Sportsbook Spread Moneyline Total

DraftKings Lions -12.5 Lions -900 / Giants +500 50.5

FanDuel Lions around -12.5 Similar moneyline range Market total in low 50s

Other books Lions -12 to -13 Heavy Detroit favorite Small variations only

Angle: Giants injuries and quarterback situation, plus the Lions strong home offense, support laying the points even with a large number.

The Colts come in with a strong record and a balanced offense, which is why this spread opened short. The market still respects Kansas City though, and the line sitting just above a field goal reflects both the Chiefs home edge and their ability to create explosive plays against a Colts defense that can be vulnerable in space.

This is a classic spot where the public may overreact to the Colts recent results and underestimate the Chiefs ability to raise their level against a quality opponent. When Kansas City protects the ball and avoids drive killing penalties, they can still separate from teams like this over four quarters, especially at home.

Sportsbook Spread Moneyline Total

DraftKings Chiefs -3.5 Chiefs -185 / Colts +154 50.5

FanDuel Chiefs -3.5 Similar moneyline range Market total around 50

Opening numbers Chiefs -4 to -3.5 Short home favorite High total from the jump

Angle: Buying a top offense at home at a short spread, with the expectation that the Chiefs ceiling performance is still higher than the Colts.

For our third pick, we go to a live underdog. The Jaguars are small road favorites, but the matchup and recent form suggest this number might be a little rich. Arizona has been more competitive at home than the market expected, and their offense has shown the ability to move the ball and score in the mid twenties against average defenses.

Jacksonville still has upside, but their defense has given up chunk plays through the air and their turnover luck from early in the season has started to come back toward the league average. If that continues, the Jaguars lose the extra possessions that helped them cover earlier in the year, and a field goal type game becomes very realistic here.

Sportsbook Spread Moneyline Total

DraftKings Jaguars -2.5 Jaguars -148 / Cardinals +124 47.5

FanDuel Jaguars -2.5 Similar moneyline range Mid to high 40s total

Market view Cards +2.5 at home Live home dog profile Potential for back and forth scoring

Angle: Home underdog with an offense that can keep pace, facing a favorite whose recent ATS profile has been inflated by early season turnover luck.

Here is a snapshot of the main lines for every Week 12 matchup. Spreads, moneylines and totals below are based on DraftKings numbers as of November 22, 2025. Lines will move, and different books may hang slightly different prices.

Game	Spread	Moneyline	Total (O/U)
Bills at Texans (final)	Bills -5.5	Bills / Texans (pre game)	43.5
Giants at Lions	Lions -12.5	Lions -900 / Giants +500	50.5
Seahawks at Titans	Seahawks -13.5	Seahawks -900 / Titans +600	40.5
Patriots at Bengals	Patriots -7.5	Patriots -375 / Bengals +295	49.5
Jets at Ravens	Ravens -13.5	Ravens -1000 / Jets +650	44.5
Colts at Chiefs	Chiefs -3.5	Chiefs -185 / Colts +154	50.5
Vikings at Packers	Packers -6	Packers -278 / Vikings +225	41.5
Steelers at Bears	Bears -2.5	Bears -148 / Steelers +124	45.5
Jaguars at Cardinals	Jaguars -2.5	Jaguars -148 / Cardinals +124	47.5
Browns at Raiders	Raiders -3.5	Raiders -192 / Browns +160	36.5
Eagles at Cowboys	Eagles -3	Eagles -170 / Cowboys +142	47.5
Falcons at Saints	Saints -2.5	Saints -135 / Falcons +114	40.5
Buccaneers at Rams	Rams -6.5	Rams -310 / Buccaneers +250	49.5
Panthers at 49ers (Monday)	49ers -7.5	49ers -375 / Panthers +295	49.5

Use this board as a starting point, then shop numbers across multiple books to find half point edges on key spreads and better prices on moneylines.